| Name: | 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane |
| CAS Number: | 423-55-2 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 207-028-4 |
| FDA UNII: | Q1D0Q7R4D9 |
| Nikkaji Web: | J94.754G |
| Beilstein Number: | 2016022 |
| MDL: | MFCD00042082 |
| XlogP3-AA: | 6.90 (est) |
| Molecular Weight: | 498.96485440 |
| Formula: | C8 Br F17 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.93000 @ 25.00 °C.
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| Boiling Point: | 141.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 6.500000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 106.00 °F. TCC ( 40.90 °C. ) (est)
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| logP (o/w): | 8.620 (est) |
| Soluble in: |
| | water, 0.0003212 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 14720 mg/kg
Microvascular Research. Vol. 8, Pg. 320, 1974.
unreported-mouse LD50 42500 mg/kg
Biomaterials, Artificial Cells, and Artificial Organs. Vol. 16, Pg. 441, 1988.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | solvents |
| Recommendation for perfluorooctyl bromide usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for perfluorooctyl bromide flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :9873 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane |
| Chemidplus:0000423552 |
| RTECS:RG8700000 for cas# 423-55-2 |
References:
| | 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9873 |
| Pubchem (sid): | 134973983 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1- | bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane | | 1- | bromoheptadecafluorooctane | | 1- | bromoperfluorooctane | | per | fluoro-N-octyl bromide | | per | fluoroctyl bromide | | per | fluoroctylbromide | | per | fluorooctylbromide | | | heptadecafluoro-N-octyl bromide | | | heptadecafluorooctyl bromide | | | imagent GI | | | octane, 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro- | | | oxygent HT | | | perflubron |
Articles:
| PubMed:Balanced UTE-SSFP for (19) F MR imaging of complex spectra. |
| PubMed:High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules. |
| PubMed:Probing different perfluorocarbons for in vivo inflammation imaging by 19F MRI: image reconstruction, biological half-lives and sensitivity. |
| PubMed:RGD decoration of PEGylated polyester nanocapsules of perfluorooctyl bromide for tumor imaging: influence of pre or post-functionalization on capsule morphology. |
| PubMed:Microfluidic fabrication of monodisperse polylactide microcapsules with tunable structures through rapid precipitation. |
| PubMed:Effects of Achilles tendon immersion in saline and perfluorochemicals on T2 and T2*. |
| PubMed:Using fluorochemical as oxygen carrier to enhance the growth of marine microalga Nannochloropsis oculata. |
| PubMed:Addition of perfluorocarbons to alginate hydrogels significantly impacts molecular transport and fracture stress. |
| PubMed:Long-circulating perfluorooctyl bromide nanocapsules for tumor imaging by 19FMRI. |
| PubMed:Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics. |
| PubMed:Interaction of melittin peptides with perfluorocarbon nanoemulsion particles. |
| PubMed:High sensitivity 19F MRI of a perfluorooctyl bromide emulsion: application to a dynamic biodistribution study and oxygen tension mapping in the mouse liver and spleen. |
| PubMed:Perfluorocarbon emulsions prevent hypoxia of pancreatic β-cells. |
| PubMed:Fluorocapsules for improved function, immunoprotection, and visualization of cellular therapeutics with MR, US, and CT imaging. |
| PubMed:Regional overdistension identified with electrical impedance tomography in the perflubron-treated lung. |
| PubMed:Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles. |
| PubMed:Partitioning of homologous nicotinic acid ester prodrugs (nicotinates) into dipalmitoylphosphatidylcholine (DPPC) membrane bilayers. |
| PubMed:The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent. |
| PubMed:Detection of fluorine labeled herceptin using cellular (19)F MRI ex vivo. |
| PubMed:Gels from a semifluorinated n-alkane in fluorinated solvents as a probe for intermolecular interactions. |
| PubMed:Non-toxicity of IV injected perfluorocarbon oxygen carrier in an animal model of liver regeneration following surgical injury. |
| PubMed:Phospholipid decoration of microcapsules containing perfluorooctyl bromide used as ultrasound contrast agents. |
| PubMed:Quantification of pegylated phospholipids decorating polymeric microcapsules of perfluorooctyl bromide by reverse phase HPLC with a charged aerosol detector. |
| PubMed:Surfactant dependent morphology of polymeric capsules of perfluorooctyl bromide: influence of polymer adsorption at the dichloromethane-water interface. |
| PubMed:Hydrogel-perfluorocarbon composite scaffold promotes oxygen transport to immobilized cells. |
| PubMed:Synthesis, physicochemical properties and in vitro cytotoxicity of nicotinic acid ester prodrugs intended for pulmonary delivery using perfluorooctyl bromide as vehicle. |
| PubMed:Perfluorocarbon emulsions cytotoxic effects on human fibroblasts and effect of aging on particle size distribution. |
| PubMed:Potential use of fluorocarbons in lung surfactant therapy. |
| PubMed:The detrimental effect of serum albumin on the re-spreading of a dipalmitoyl phosphatidylcholine Langmuir monolayer is counteracted by a fluorocarbon gas. |
| PubMed:Two-compartment radial diffusive exchange analysis of the NMR lineshape of (129)Xe dissolved in a perfluorooctyl bromide emulsion. |
| PubMed:Polymeric nano/microcapsules of liquid perfluorocarbons for ultrasonic imaging: physical characterization. |
| PubMed:Fluidization of a dipalmitoyl phosphatidylcholine monolayer by fluorocarbon gases: potential use in lung surfactant therapy. |
| PubMed:Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144. |
| PubMed:Intrapulmonary perfluorooctyl bromide instillation in fetal rabbits. |
| PubMed:Cosurfactant effect of a semifluorinated alkane at a fluorocarbon/water interface: impact on the stabilization of fluorocarbon-in-water emulsions. |
| PubMed:Understanding the fundamentals of perfluorocarbons and perfluorocarbon emulsions relevant to in vivo oxygen delivery. |
| PubMed:Molecular dynamics averaging of Xe chemical shifts in liquids. |
| PubMed:Artificial oxygen carriers as red blood cell substitutes: a selected review and current status. |
| PubMed:Effect of meconium on the surface properties of perflubron. |
| PubMed:Mechanism of perfluoroalkyl halide toxicity: catalysis of perfluoroalkylation by reduced forms of cobalamin (vitamin B12). |
| PubMed:Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. |
| PubMed:Effect of perfluorooctyl bromide on bacterial growth. |
| PubMed:Pulmonary drug delivery systems: recent developments and prospects. |
| PubMed:Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization. |
| PubMed:Combined bactericidal activity of perfluorooctyl bromide and aminoglycosides against Pseudomonas aeruginosa. |
| PubMed:Perfluorooctyl bromide has limited membrane solubility and is located at the bilayer center. Locating small molecules in lipid bilayers through paramagnetic enhancements of NMR relaxation. |
| PubMed:Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate. |
| PubMed:Effect of perfluorocarbon (perfluorooctyl bromide) vapor on tidal volume measurement during partial liquid ventilation. |
| PubMed:Reverse water-in-fluorocarbon emulsions for use in pressurized metered-dose inhalers containing hydrofluoroalkane propellants. |
| PubMed:Improvements in the ultrasonic contrast of targeted perfluorocarbon nanoparticles using an acoustic transmission line model. |
| PubMed:Pulmonary arterial morphometry from microfocal X-ray computed tomography. |
| PubMed:Microfocal X-ray CT imaging and pulmonary arterial distensibility in excised rat lungs. |
| PubMed:Compatibility of different colloid plasma expanders with perflubron emulsion: an intravital microscopic study in the hamster. |
| PubMed:Assay method for the perfluorooctyl bromide (perflubron) in rat blood by gas chromatography-mass spectrometry. |
| PubMed:Perfluorocarbon emulsions as intravenous delivery media for hyperpolarized xenon. |
| PubMed:Solubility enhancement of phenol and phenol derivatives in perfluorooctyl bromide. |
| PubMed:Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea. |
| PubMed:Influence of intravenous perfluorocarbon administration on the dynamic behavior of lung surfactant. |
| PubMed:Perfluorocarbon induced alterations in pulmonary mechanics. |
| PubMed:Effects of perfluorocarbon emulsions on cultured human endothelial cells. |
| PubMed:Aerobic preservation of organs using a new perflubron/lecithin emulsion stabilized by molecular dowels. |
| PubMed:Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon. |
| PubMed:Time versus density enhancement of liver, spleen, and great vessels following rapid intravenous infusion of perflubron emulsion. |
| PubMed:Rat multiple organ blocks perfused with perfluorooctyl bromide emulsions. |
| PubMed:Improvement in circulatory and oxygenation status by perflubron emulsion (Oxygent HT) in a canine model of surgical hemodilution. |
| PubMed:Characterization and mechanism of side-effects of Oxygent HT (highly concentrated fluorocarbon emulsion) in swine. |
| PubMed:Normothermic preservation of "multiple organ blocks" with a new perfluorooctyl bromide emulsion. |
| PubMed:Intracellular and extracellular transport of perfluoro carbon emulsion from subcutaneous tissue to regional lymphatics. |
| PubMed:Novel injectable fluorinated contrast agents with enhanced radiopacity. |
| PubMed:Oxygenation during perfluorocarbon associated gas exchange in normal and abnormal lungs. |
| PubMed:Effects of formulation, processing and storage parameters on the characteristics and stability of perflubron emulsion. |
| PubMed:Effects of buffer pH and phosphate concentration on the droplet size and EYP hydrolysis of perflubron/EYP emulsions. |
| PubMed:Mixed fluorocarbon/hydrocarbon molecular dowels help protect concentrated fluorocarbon emulsions with large size droplets against coalescence. |
| PubMed:Lung functions after intravenous or intraperitoneal administration of perfluorooctyl bromide (PFOB) or perfluorotributylamine (FTBA) emulsions. |
| PubMed:Perfluorocarbon distribution to liver, lung and spleen of emulsions of perfluorotributylamine (FTBA) in pigs and rats and perfluorooctyl bromide (PFOB) in rats and dogs by 19F NMR spectroscopy. |
| PubMed:Phagocytosis of a fluorescently labeled perflubron emulsion by a human monocyte cell line. |
| PubMed:Improved control over particle sizes and stability of concentrated fluorocarbon emulsions by using mixed fluorocarbon/hydrocarbon molecular dowels. |
| PubMed:Room temperature stable perfluorocarbon emulsions with acceptable half-lives in the reticuloendothelial system. |
| PubMed:Influence of perflubron emulsion particle size on blood half-life and febrile response in rats. |
| PubMed:Enhanced oxygen delivery by perflubron emulsion during acute hemodilution. |
| PubMed:Ex vivo normothermic preservation of rat multiple organ blocks using a perfluorooctyl bromide emulsion as oxygen carrier. |
| PubMed:Value of brominated fluorocarbons for the radiographic diagnosis of small-bowel obstruction: comparison with other contrast agents in rats. |
| PubMed:Radiosensitivity, blood perfusion and tumour oxygenation after perflubron emulsion injection. |
| PubMed:A new perfluorocarbon for use in fluorine-19 magnetic resonance imaging and spectroscopy. |
| PubMed:Inhibition of endotoxin-mediated activation of endothelial cells by a perfluorocarbon emulsion. |
| PubMed:Perfluorooctyl bromide dispersions in aqueous media for biomedical applications. |
| PubMed:New perfluorocarbon emulsion improves tissue oxygenation in cat retina. |
| PubMed:Correction of chemical-shift artifacts in multislice F-19 imaging with perfluorooctyl bromide. |
| PubMed:A new concentrated perfluorochemical emulsion and carbogen breathing as an adjuvant to treatment with antitumor alkylating agents. |
| PubMed:Overview of progress in the fluorocarbon approach to in vivo oxygen delivery. |
| PubMed:Influence of the 100% w/v perfluorooctyl bromide (PFOB) emulsion dose on tumour radiosensitivity. |
| PubMed:Detection of tumors with 19F magnetic resonance imaging. |
| PubMed:Rapid 19F magnetic resonance imaging of perfluorooctyl bromide in vivo. |
| PubMed:Perfluorooctyl bromide concentration in plasma and tissues of beagle dogs. |
| PubMed:Perfluorooctyl bromide: a potential antiobesity compound. |
| PubMed:Perfluoro carbon bromides as contrast media in radiography of the central nervous system. A preliminary experimental report. |
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